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・ Interleukin 28 receptor, alpha subunit
・ Interleukin 28B
・ Interleukin 29
・ Interleukin 3
・ Interleukin 30
・ Interleukin 31
・ Interleukin 32
・ Interleukin 33
・ Interleukin 34
・ Interleukin 35
・ Interleukin 36 receptor antagonist
・ Interleukin 37
・ Interleukin 4
・ Interleukin 5
・ Interleukin 5 receptor alpha subunit
Interleukin 6
・ Interleukin 7
・ Interleukin 8
・ Interleukin 8 receptor, alpha
・ Interleukin 8 receptor, beta
・ Interleukin 9
・ Interleukin receptor
・ Interleukin-1 receptor
・ Interleukin-1 receptor family
・ Interleukin-1 receptor-associated kinase
・ Interleukin-1 receptor–associated kinase 4 deficiency
・ Interleukin-10 receptor
・ Interleukin-11 receptor
・ Interleukin-12 receptor
・ Interleukin-13 receptor


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Interleukin 6 : ウィキペディア英語版
Interleukin 6

Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the ''IL6'' gene.
IL-6 is secreted by T cells and macrophages to stimulate immune response, e.g. during infection and after trauma, especially burns or other tissue damage leading to inflammation. IL-6 also plays a role in fighting infection, as IL-6 has been shown in mice to be required for resistance against bacterium ''Streptococcus pneumoniae''.
In addition, osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine. IL-6's role as an anti-inflammatory cytokine is mediated through its inhibitory effects on TNF-alpha and IL-1, and activation of IL-1ra and IL-10.
== Function ==

IL-6 is an important mediator of fever and of the acute phase response. It is capable of crossing the blood-brain barrier and initiating synthesis of PGE2 in the hypothalamus, thereby changing the body's temperature setpoint. In muscle and fatty tissue, IL-6 stimulates energy mobilization that leads to increased body temperature. IL-6 can be secreted by macrophages in response to specific microbial molecules, referred to as pathogen-associated molecular patterns (PAMPs). These PAMPs bind to an important group of detection molecules of the innate immune system, called pattern recognition receptors (PRRs), including Toll-like receptors (TLRs). These are present on the cell surface and intracellular compartments and induce intracellular signaling cascades that give rise to inflammatory cytokine production.
IL-6 is also essential for hybridoma growth and is found in many supplemental cloning media such as briclone. Inhibitors of IL-6 (including estrogen) are used to treat postmenopausal osteoporosis. IL-6 is also produced by adipocytes and is thought to be a reason why obese individuals have higher endogeneous levels of CRP. Intranasally administered IL-6 has been shown to improve sleep-associated consolidation of emotional memories.
IL-6 is responsible for stimulating acute phase protein synthesis, as well as the production of neutrophils in the bone marrow. It supports the growth of B cells and is antagonistic to regulatory T cells.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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